There’s good news and bad news
about brain cancer treatment. The good news is that Fernando Safdie of the
University of Southern California and his colleagues may have found a way to
boost the effects of chemotherapy and radiotherapy without damaging healthy
cells. The bad news is that the method involves starvation.
The most common type of brain
cancer is glioma. Treatment usually includes surgery, radiation and
chemotherapy, but even with all that the five-year survival rate is less than
3%. The standard chemotherapy drug for this type of cancer is Temozolomide
(TMZ) but it can only temporarily halt the growth of brain tumors. Meanwhile,
these treatments damage healthy tissue as well as cancerous cells. Obviously, any approach that can improve these odds is worth investigating.
Why pursue fasting as a
treatment? Unlike normal cells, under times of duress, cancer cells don’t transfer scant resources
from growth to maintenance functions. Thus, the tumor cells are particularly
vulnerable to starvation. The researchers hope that fasting can cause these
toxic therapies (chemotherapy and radiotherapy) to preferentially attack tumors rather than healthy tissues.
‘Short-term starvation’ was
tested both in vitro, with glioma
cell cultures, and in mice. In both cases, tumor cells but not normal cells were
sensitized to TMZ. In fact, starvation alone slowed tumor growth as much as
chemotherapy alone, though the greatest benefit was seen with fasting and
chemotherapy. Mice that fasted and got TMZ had the smallest tumors and survived the longest. The same
pattern held for radiotherapy. Mice that had been deprived of food had the best
outcomes.
Safdie F, Brandhorst S, Wei M, Wang W, Lee C, Hwang S, Conti PS, Chen TC, & Longo VD (2012). Fasting enhances the response of glioma to chemo- and radiotherapy. PloS one, 7 (9) PMID: 22984531
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