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Thursday, October 24, 2013

Inherited herpes virus


File:Hhv-6.jpg
HHV-6 being released from a lymphocyte
Three words you don’t want to hear are ‘inherited herpes virus’. It’s bad enough that herpes is so contagious, but now we learn that the virus can be integrated into the genome. In other words, according to researchers led by Yan Huang of the University of Leicester, some people are conceived with herpes. To make matters worse, herpes virus can ‘escape’ from its chromosomal home and become a free agent. 
There are actually lots of different human herpes viruses (HHVs). You know one common type (HHV-3) as chickenpox. Most of these viruses can lay low in the body, persisting without detection for many decades. However, the viral nucleic acids usually remain separate from those of the host. In the case of HHV-6, the researchers found that the viral DNA had become incorporated into the host cell's genome. Apparently, about 0.8% of the British population were HHV-6 carriers.

More specifically, the virus integrates into the telomeres at the ends of chromosomes. This region is particularly unstable and made more so by the addition of the viral DNA. This makes it more likely that the viral DNA will be shed from the ends of the chromosomes. Once this happens, it’s possible for the virus to infect new cells. 

These data suggest that a person could be born with HHV-6 already present within the DNA he inherited from a parent, and that the embedded virus could at any point cause a full blown infection. While this isn’t good news for anyone, it’s especially problematic for immuno-compromised blood and organ recipients. Currently, donation programs screen blood products for infectious agents but not for gene sequences that might become reactivated at any moment.


Yan Huang, Alberto Hidalgo-Bravo, Enjie Zhang, Victoria E. Cotton, Aaron Mendez-Bermudez, Gunjan Wig, Zahara Medina-Calzada, Rita Neumann, Alec J. Jeffreys1, Bruce Winney2, James F. Wilson3, Duncan A. Clark, Martin J. Dyer, & Nicola J. Royle (2013). Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome Nucleic Acids Research DOI: 10.1093/nar/gkt840.



3 comments:

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  2. i am Mr James Wright I never believe there is herpes cure until i have encounter with doctor oduwa. Let me share a little on how i got cured from Genital Herpes. When I stumbled upon a website, while I was looking for Herpes cure on a forum that I frequently visited, the first thing that I noticed was that most persons there was testifying and thanking Doctor Oduwa and i went through the write up and i read about how doctor Oduwa has cure them and first i went into doubt but i have to see what he can do for me with tears in my eyes because i want to be free from this disease. i contacted the herbal doctor through his email, after writing him about my problem, he assured me that he will help me get this disease out of me. that he is only here to help people and and also put smile on their faces. He told me that his herbal medicine is free that the only thing that i need to provide is the items that he will use to prepare the herbal medicine and after going according to doctor Oduwa instruction. few days later he send the herbal medicine to me via courier service use the herbal medicine for 3 days and i went back for a medical checkup and according to the words doctor Oduwa gave to me really work for me by curing my herpes, now i believe him and i telling you, if have been infected either with HERPES, and CANCER E.T.C. i assure you that doctor Oduwa can also cure you. i have seen a testimonies of people and I'm also one of the living testimony. here is doctor Oduwa email........ dr.oduwaspellhome@gmail.com or contact him via or add him on whatsapp +2348070685053

    ReplyDelete
  3. two year ago i got hsv.... which i have spent a lot of money to get a ride of, so few month a ago a friend introduce me to a natural herbalist healer...... who prepare me a natural herbal treatment which i only took within the proud of 2 weeks and i got cured totally without any bad effect ...contact Dr isibor via email: drisiborspellhome@gmail.com or his whatsApp contact +2348107855231.

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